梅毒螺旋体抗体明胶凝集试验（ID-PaGIA）的评价。
Evaluation of ID-PaGIA syphilis antibody test.
机构信息
Department of Medical Microbiology, Stavanger University Hospital, and United Laboratories, Tartu University Hospital, Estonia, Norway.
出版信息
Indian J Dermatol Venereol Leprol. 2009 Sep-Oct;75(5):492-4. doi: 10.4103/0378-6323.55393.
BACKGROUND
Laboratory diagnosis of syphilis is usually accomplished by serology. There are currently a large number of different commercial treponemal tests available that vary in format, sensitivity and specificity.
AIM
To evaluate the ID-PaGIA Syphilis Antibody Test as an alternative to other specific treponemal tests for primary screening or confirmation of diagnosis.
METHODS
Serum samples from healthy adults (n = 100) were used for detection of specificity of ID-PaGIA. To evaluate sensitivity of ID-PaGIA serum samples (n = 101) from patients with confirmed or suspected syphilis were tested for syphilis antibodies with FTA-Abs IgM, ID-PaGIA, ELISA IgM and TPHA tests.
RESULTS
No false-positive results were found with ID-PaGIA. Sensitivity of various treponemal tests was the following: FTA-Abs IgM: 95.5%, ID-PaGIA and ELISA IgM: 94%, and TPHA 75%. The positive and negative predictive values of ID-PaGIA were 100 and 89.5%, respectively.
CONCLUSIONS
Compared with other treponemal tests ID-PaGIA has excellent sensitivity and specificity.
背景
梅毒的实验室诊断通常通过血清学来完成。目前有大量不同的商业化密螺旋体检测方法，它们在格式、灵敏度和特异性方面存在差异。
目的
评估 ID-PaGIA 梅毒抗体检测作为其他特定密螺旋体检测的替代方法，用于初筛或诊断确认。
方法
使用来自健康成年人的血清样本（n = 100）评估 ID-PaGIA 的特异性。为了评估 ID-PaGIA 的灵敏度，对来自确诊或疑似梅毒患者的血清样本（n = 101）进行了 FTA-Abs IgM、ID-PaGIA、ELISA IgM 和 TPHA 检测。
结果
ID-PaGIA 未出现假阳性结果。各种密螺旋体检测的灵敏度如下：FTA-Abs IgM：95.5%，ID-PaGIA 和 ELISA IgM：94%，TPHA 为 75%。ID-PaGIA 的阳性和阴性预测值分别为 100%和 89.5%。
结论
与其他密螺旋体检测相比，ID-PaGIA 具有出色的灵敏度和特异性。
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