Department of Dermatology, Adan Hospital, Kuwait.
Indian J Dermatol Venereol Leprol. 2009 Sep-Oct;75(5):503-5. doi: 10.4103/0378-6323.55396.
The metastasis of a visceral malignancy to the umbilicus is known as "Sister Mary Joseph's nodule". It is a rare clinical sign indicating advanced, metastasizing intraabdominal cancer. We report a 50-year-old man who developed metastatic skin cancer in the form of semicircular indurated plaque on top of which was a firm mobile rounded nodule at the umbilical area. Histopathological examination demonstrated diastase-resistant periodic acid-Schiff and mucicarmine positive signet ring cells, suggesting gastric carcinoma. Immunohistochemical staining showed that these cells were positive for cytokeratins and epithelial membrane antigen, suggesting epithelial origin.
内脏恶性肿瘤转移至脐部被称为“修女玛丽·约瑟夫结节”。这是一种罕见的临床征象，提示为晚期、转移性腹腔内癌症。我们报告了 1 例 50 岁男性，其在脐部出现半圆形硬结斑块，斑块上有 1 个坚实可移动的圆形结节，诊断为转移性皮肤癌。组织病理学检查显示耐消化酶的过碘酸雪夫和粘卡红阳性的印戒细胞，提示为胃癌。免疫组织化学染色显示这些细胞角蛋白和上皮膜抗原阳性，提示上皮来源。
