蛋白精氨酸脱亚氨酶4（PAD4）：当前的认识与未来的治疗潜力
Protein arginine deiminase 4 (PAD4): Current understanding and future therapeutic potential.
作者信息
Jones Justin E, Causey Corey P, Knuckley Bryan, Slack-Noyes Jessica L, Thompson Paul R
机构信息
University of South Carolina, Department of Chemistry & Biochemistry, Columbia, 29208, USA.
出版信息
Curr Opin Drug Discov Devel. 2009 Sep;12(5):616-27.
Abstract
The protein arginine deiminases (PADs), and in particular PAD4, have emerged as potential therapeutic targets for the treatment of rheumatoid arthritis (RA). In this review, evidence linking dysregulated PAD activity to the onset and progression of RA is presented, and the potential role of such aberrant activity in other human diseases, such as multiple sclerosis and cancer, is discussed. The known physiological roles of the PADs, particularly PAD4, and current knowledge regarding PAD structure, catalysis and inhibition are also described.
摘要
蛋白质精氨酸脱亚氨酶（PADs），尤其是PAD4，已成为治疗类风湿性关节炎（RA）的潜在治疗靶点。在本综述中，展示了将失调的PAD活性与RA的发病和进展联系起来的证据，并讨论了这种异常活性在其他人类疾病（如多发性硬化症和癌症）中的潜在作用。还描述了PADs，特别是PAD4的已知生理作用，以及目前关于PAD结构、催化和抑制的知识。
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Retinal deimination in aging and disease.衰老和疾病中的视网膜脱氨作用。
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A functional haplotype of PADI4 gene in rheumatoid arthritis: positive correlation in a French population.类风湿关节炎中PADI4基因的一个功能性单倍型：在法国人群中的正相关性。
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Porphyromonas gingivalis may play an important role in the pathogenesis of periodontitis-associated rheumatoid arthritis.牙龈卟啉单胞菌可能在牙周炎相关性类风湿关节炎的发病机制中起重要作用。
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Increased PADI4 expression in blood and tissues of patients with malignant tumors.恶性肿瘤患者血液和组织中PADI4表达增加。
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Accumulation of citrullinated proteins by up-regulated peptidylarginine deiminase 2 in brains of scrapie-infected mice: a possible role in pathogenesis.在感染瘙痒病的小鼠大脑中，上调的肽基精氨酸脱氨酶2导致瓜氨酸化蛋白的积累：其在发病机制中的可能作用。
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