Jones Justin E, Causey Corey P, Knuckley Bryan, Slack-Noyes Jessica L, Thompson Paul R
University of South Carolina, Department of Chemistry & Biochemistry, Columbia, 29208, USA.
Curr Opin Drug Discov Devel. 2009 Sep;12(5):616-27.
The protein arginine deiminases (PADs), and in particular PAD4, have emerged as potential therapeutic targets for the treatment of rheumatoid arthritis (RA). In this review, evidence linking dysregulated PAD activity to the onset and progression of RA is presented, and the potential role of such aberrant activity in other human diseases, such as multiple sclerosis and cancer, is discussed. The known physiological roles of the PADs, particularly PAD4, and current knowledge regarding PAD structure, catalysis and inhibition are also described.
蛋白质精氨酸脱亚氨酶（PADs），尤其是PAD4，已成为治疗类风湿性关节炎（RA）的潜在治疗靶点。在本综述中，展示了将失调的PAD活性与RA的发病和进展联系起来的证据，并讨论了这种异常活性在其他人类疾病（如多发性硬化症和癌症）中的潜在作用。还描述了PADs，特别是PAD4的已知生理作用，以及目前关于PAD结构、催化和抑制的知识。
