短缩酰胺的全合成。

Total synthesis of brevisamide.

作者信息

Lee Jihoon, Panek James S

机构信息

Department of Chemistry, Metcalf Center for Science and Engineering, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, USA.

出版信息

Org Lett. 2009 Oct 1;11(19):4390-3. doi: 10.1021/ol901801h.

DOI:10.1021/ol901801h

PMID:19736917

Abstract

A convergent synthesis of brevisamide (1) is described based on the application of the crotyl silane-based [4 + 2]-annulation used for the preparation of the advanced oxygenated tetrahydropyran intermediate 2. The side chain bearing a conjugated (E,E)-diene was efficiently constructed under modified Negishi cross-coupling conditions.

摘要

基于用于制备高级氧化四氢吡喃中间体2的基于巴豆基硅烷的[4+2]环化反应，描述了短酰胺（1）的汇聚合成。在改良的根岸交叉偶联条件下，有效地构建了带有共轭（E，E）-二烯的侧链。