Hall Heather E, Hawley R Scott
Stowers Institute for Medical Research, Kansas City, MO 64110, USA.
Cell. 2009 Sep 4;138(5):830-2. doi: 10.1016/j.cell.2009.08.022.
Much of the Y chromosome consists of large palindromic arrays harboring genes that are critical for spermatogenesis. In this issue, Lange et al. (2009) show that although gene conversion within these arrays maintains their integrity, it also permits rare unequal sister chromatid-exchange events within palindromes that create unstable dicentric chromosomes, resulting in infertility, sex reversal, and Turner syndrome.
Y染色体的大部分由大型回文阵列组成，这些阵列包含对精子发生至关重要的基因。在本期中，兰格等人（2009年）表明，尽管这些阵列中的基因转换维持了它们的完整性，但它也允许在回文结构内发生罕见的不等姐妹染色单体交换事件，从而产生不稳定的双着丝粒染色体，导致不育、性反转和特纳综合征。
