Kark Malin, Rasmussen Finn
Child and Adolescent Public Health Epidemiology Group, Department of Public Health Sciences, Karolinska Institute, Sweden.
Eur J Cardiovasc Prev Rehabil. 2009 Oct;16(5):597-602. doi: 10.1097/HJR.0b013e32832d7ce0.
Hypertension puts a heavy economic burden on society through large medical care expenditures and productivity losses resulting from disability and premature death. The risk of obtaining a disability pension (DP) because of cardiovascular disease (CVD) has not been explored in previous research. The aim of this study was to investigate the extent to which high systolic blood pressure (BP) among 18-year-old men increases the risk of obtaining a DP in later life, for any reason or specifically because of CVD, compared with men with normal systolic BP.
DESIGN/METHODS: A record linkage was performed involving several nation-wide Swedish registers. The study cohort consisted of men born between 1951 and 1970 who underwent military conscription during 1969-1994, when they were 17-20 years of age. Data on BP, weight, height and muscle strength were obtained from conscription examinations, and information on DP and the underlying International Classification of Diseases diagnosis were retrieved from the Social Insurance Office 1971-2006. Analyses were conducted by Cox proportional hazards regression models with adjustment for several confounding factors.
Among 903 174 men with complete data, mean follow-up time was 26.8 years and 54 524 men (6.0%) attained DP. The risk of obtaining a DP because of CVD among men with moderate/severe hypertension (systolic BP> or =160 mmHg) was moderately increased, fully adjusted hazard ratio = 1.52 (95% confidence interval=1.04-2.22) compared with men with normal systolic BP.
This large population-based cohort study showed that moderate/severe hypertension in young adulthood conveyed an increased risk of obtaining a DP caused by CVD. Primary prevention of hypertension and optimal early treatment of hypertension may reduce productivity losses because of DP caused by CVD.
高血压通过巨额医疗费用以及因残疾和过早死亡导致的生产力损失给社会带来沉重的经济负担。以往研究尚未探讨因心血管疾病(CVD)而获得残疾抚恤金(DP)的风险。本研究的目的是调查与收缩压正常的男性相比,18岁男性中高收缩压在多大程度上会增加其在晚年因任何原因或具体因CVD而获得DP的风险。
设计/方法:进行了一项涉及瑞典多个全国性登记处的记录链接研究。研究队列由1951年至1970年出生、在1969 - 1994年17 - 20岁时接受兵役登记的男性组成。血压、体重、身高和肌肉力量的数据来自征兵检查,残疾抚恤金和潜在的国际疾病分类诊断信息则从社会保险办公室1971 - 2006年的记录中获取。通过Cox比例风险回归模型进行分析,并对多个混杂因素进行了调整。
在903174名有完整数据的男性中,平均随访时间为26.8年,54524名男性(6.0%)获得了残疾抚恤金。与收缩压正常的男性相比,中度/重度高血压(收缩压≥160 mmHg)男性因CVD获得DP的风险适度增加,完全调整后的风险比为1.52(95%置信区间 = 1.04 - 2.22)。
这项基于大规模人群的队列研究表明,成年早期的中度/重度高血压会增加因CVD导致获得DP的风险。高血压的一级预防和最佳早期治疗可能会减少因CVD导致的残疾抚恤金所造成的生产力损失。