大鼠识别记忆的个体发生：新颖物体识别任务的测量。
Ontogeny of Rat Recognition Memory measured by the novel object recognition task.
机构信息
Department of Neurosurgery, University of California, Los Angeles, CA 90095, USA.
出版信息
Dev Psychobiol. 2009 Dec;51(8):672-8. doi: 10.1002/dev.20402.
Abstract
Detection of novelty is an essential component of recognition memory, which develops throughout cerebral maturation. To better understand the developmental aspects of this memory system, the novel object recognition task (NOR) was used with the immature rat and ontogenically profiled. It was hypothesized that object recognition would vary across development and be inferior to adult performance. The NOR design was made age-appropriate by downsizing the testing objects and arena. Weanling (P20-23), juvenile (P29-40), and adult (P50+) rats were tested after 0.25, 1, 24, and 48 hr delays. Weanlings exhibited novel object recognition at 0.25 and 1 hr, while older animals showed a preference for the novel object out to 24 hr. These findings are consistent with previous research performed in humans and monkeys, as well as to studies using the NOR after medial temporal lobe damage in adult rats.
摘要
新颖性检测是识别记忆的一个重要组成部分，它在大脑成熟过程中不断发展。为了更好地理解这个记忆系统的发展方面，使用不成熟的大鼠进行了新物体识别任务（NOR），并进行了个体发育分析。研究假设物体识别会随年龄而变化，并且不如成人表现。通过缩小测试物体和竞技场的尺寸，使 NOR 设计适应年龄。新生（P20-23）、幼体（P29-40）和成年（P50+）大鼠在 0.25、1、24 和 48 小时延迟后进行测试。新生大鼠在 0.25 和 1 小时时表现出新颖物体识别，而年龄较大的动物在 24 小时时表现出对新物体的偏好。这些发现与以前在人类和猴子中进行的研究以及在成年大鼠的内侧颞叶损伤后使用 NOR 进行的研究一致。
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