精胺对兔骨骼肌磷酸化酶磷酸酶的抑制作用。
Inhibition of rabbit skeletal muscle phosphorylase phosphatase by spermine.
作者信息
Nakai C, Glinsmann W
出版信息
Mol Cell Biochem. 1977 Apr 12;15(2):141-3. doi: 10.1007/BF01793336.
PMID:197399
Abstract
The effect of three naturally occurring polyamines (putrescine, spermidine, and spermine) on the activity of rabbit skeletal muscle phosphorylase phosphatase was investigated. Only spermine significantly inhibited the enzyme. The mode of inhibition (ki value of 0.3 mM) of the phosphatase by spermine appears to be different from that caused by divalent metal ions or by other organic cations, such as arginine and lysine esters, since it is noncompetitive with respect to the substrate, phosphorylase a.
摘要
研究了三种天然存在的多胺（腐胺、亚精胺和精胺）对兔骨骼肌磷酸化酶磷酸酶活性的影响。只有精胺能显著抑制该酶。精胺对磷酸酶的抑制模式（Ki值为0.3 mM）似乎不同于二价金属离子或其他有机阳离子（如精氨酸和赖氨酸酯）所引起的抑制模式，因为它对底物磷酸化酶a是非竞争性的。
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