Department of Neurology, The Sagol Neuroscience Center, Sheba Medical Center, Tel Hashomer and Tel Aviv University, Israel.
J Neurol Sci. 2010 Feb 15;289(1-2):23-6. doi: 10.1016/j.jns.2009.08.015. Epub 2009 Sep 8.
The occurrence of dementia in genetic Parkinson's disease is heterogeneous. The onset and progression of diverse forms of familial Parkinson's disease might be different than that of sporadic disease. Since dementia is an age related process, its risk increases with advanced disease severity and duration. The onset and progression of dementia is expected to vary between genetic forms, which present at diverse ages with different symptomatologies. It seems that genetic Parkinson's disease variants in which Lewy bodies are the prominent pathological hallmark - such as in PARK1, PARK4 and PARK8 - dementia is part of the phenotype. On the contrary, in PARK2 which is not accompanied by Lewy body accumulation, patients do not show a systematic cognitive decline. This review presents information on dementia in genetic forms of Parkinson's disease.
遗传性帕金森病患者中痴呆的发生具有异质性。不同形式的家族性帕金森病的发病和进展可能与散发性疾病不同。由于痴呆是一种与年龄相关的过程，其风险随着疾病严重程度和持续时间的增加而增加。预计不同遗传形式的痴呆发病和进展会有所不同，这些遗传形式在不同的年龄出现，具有不同的症状。似乎在以路易体为主要病理特征的遗传帕金森病变异中，如 PARK1、PARK4 和 PARK8，痴呆是表型的一部分。相反，在不伴有路易体堆积的 PARK2 中，患者不会出现系统性认知下降。这篇综述介绍了遗传形式帕金森病患者痴呆的相关信息。
