del Busto Prado F, Alvarez García A, Ibarra Peláez A, Menéndez Fernándéz J, Barraca de Ramos R, Alonso Calo L
Servicio de Urgencias, Hospital Covadonga, Oviedo.
Med Clin (Barc). 1990 Apr 28;94(16):616-8.
Thirty-five patients over 14 years of age were evaluated, with the common feature of benzodiazepine poisoning, either as a single drug or associated with others and/or with ethanol, and who had a Glasgow score lower than 10 at admission. These patients were treated with flumazenil as a competitive antagonist drug. The results were very satisfactory. Subsequently, the possible relationship between the effect of flumazenil and the pharmacokinetic benzodiazepine profile was evaluated, and a significant relationship between the half life and the degree of resedation of the patients was found.
