Simavorian P S, Martirosian O M, Shirinian E A
Patol Fiziol Eksp Ter. 1990 Mar-Apr(2):20-2.
Experiments were conducted on pithed rats with acute pancreatitis and on falsely operated on animals (ether-laparotomy stress) to study the reactivity of vascular alpha 1- and alpha 2-adrenoreceptors and its role in changes in arterial pressure. Selective change in the reactivity of alpha 2-adrenoceptors alone was revealed in both groups. Stable reduction of vascular alpha 2-adrenergic reactivity (by 57-58%) and arterial pressure was recorded in animals with acute pancreatitis. In falsely operated on animals, in contrast, the values of these indices exceeded the control level. In animals with a functioning central nervous system inhibition of alpha 2-adrenergic reactivity correlated with change in arterial pressure only in the initial (3-4 hours) hemorrhagic phase of acute pancreatitis.
对患有急性胰腺炎的去大脑大鼠以及接受假手术的动物（乙醚剖腹手术应激）进行了实验，以研究血管α1和α2肾上腺素能受体的反应性及其在动脉血压变化中的作用。两组均发现仅α2肾上腺素能受体反应性发生了选择性变化。在患有急性胰腺炎的动物中，记录到血管α2肾上腺素能反应性稳定降低（降低57 - 58%）以及动脉血压降低。相比之下，在接受假手术的动物中，这些指标的值超过了对照水平。在具有正常中枢神经系统功能的动物中，仅在急性胰腺炎的初始（3 - 4小时）出血期，α2肾上腺素能反应性的抑制与动脉血压变化相关。
