The Norwegian Arthroplasty Register, Department of Orthopaedic Surgery, Haukeland University Hospital, N-5021 Bergen, Norway.
Cancer Epidemiol. 2009 Oct;33(3-4):235-41. doi: 10.1016/j.canep.2009.06.009. Epub 2009 Sep 9.
To investigate whether cancer patients have an increased risk of receiving a total hip replacement compared to the standard population of Norway.
By linking of The Cancer Register of Norway and The Norwegian Arthroplasty Register we obtained information on cancer diagnoses (type, date of diagnosis), total hip arthroplasties and date of death for all patients living in Norway. This includes 741,901 patients categorized into three groups: 652,197 patients with at least one cancer diagnosis but no hip arthroplasties, 72,469 patients with at least one hip arthroplasty but no cancer diagnosis and 17,235 patients who have at least one cancer diagnosis and at least one hip arthroplasty. Within this latter group, 8563 individuals had been diagnosed with cancer prior to a total hip arthroplasty. Statistical methods applied in this study were Cox interval censored regression models and standardized incidence ratios (SIR).
Cancer patients had a slightly increased risk of receiving a total hip arthroplasty compared to the Norwegian population (SIR=1.15 (95% CI, 1.12-1.17)). For primary tumours located cranially to the pelvic area there was no significant increase in risk for hip arthroplasty. An exception was breast cancer (SIR=1.13 (95% CI 1.08-1.18)). Cancer located in the pelvic region (SIR=1.20 (95% CI 1.16-1.24)), malignant lymphoma (SIR=1.30 (95% CI 1.15-1.46)) and leukaemia (SIR=1.17 (95% CI 1.01-1.34)) had an increased risk for receiving a total hip arthroplasty.
Cancer survivors, mainly those with pelvic and lympho-hematological malignancies, have a small statistically significant increase in risk for receiving total hip arthroplasty.
调查癌症患者接受全髋关节置换术的风险是否高于挪威标准人群。
通过链接挪威癌症登记处和挪威关节置换登记处，我们获得了所有居住在挪威的患者的癌症诊断（类型、诊断日期）、全髋关节置换术和死亡日期的信息。这包括 741901 名患者，分为三组：652197 名至少有一次癌症诊断但没有髋关节置换术的患者，72469 名至少有一次髋关节置换术但没有癌症诊断的患者，以及 17235 名至少有一次癌症诊断和至少一次髋关节置换术的患者。在后一组中，有 8563 人在接受全髋关节置换术前被诊断患有癌症。本研究中应用的统计方法是 Cox 区间censored 回归模型和标准化发病比（SIR）。
与挪威人群相比，癌症患者接受全髋关节置换术的风险略高（SIR=1.15（95% CI，1.12-1.17））。对于位于骨盆区域以上的原发性肿瘤，髋关节置换术的风险没有显著增加。乳腺癌是一个例外（SIR=1.13（95% CI 1.08-1.18））。位于骨盆区域的癌症（SIR=1.20（95% CI 1.16-1.24））、恶性淋巴瘤（SIR=1.30（95% CI 1.15-1.46））和白血病（SIR=1.17（95% CI 1.01-1.34））接受全髋关节置换术的风险增加。
癌症幸存者，主要是那些患有骨盆和淋巴血液恶性肿瘤的患者，接受全髋关节置换术的风险略有统计学意义的增加。
