Krönig B, Widmann L, Staiger C, Machwirth M, Stienen U, Hennig M, Müller-Beckmann B
Department of Internal Medicine, Elisabeth-Hospital, Trier, Federal Republic of Germany.
Eur J Clin Pharmacol. 1990;38 Suppl 2:S167-70. doi: 10.1007/BF01409490.
Carvedilol and nitrendipine were given for 12 weeks in a double-blind study to 81 elderly patients (greater than or equal to 60 years) with essential hypertension. The effects on blood pressure were measured (Riva Rocci) before medication and after 2 h with the patient in a lying and standing position after 4 weeks of placebo therapy as well as after 4, 8 and 12 weeks of treatment. Carvedilol (25 mg/o.d.) reduced blood pressure measured in the supine and erect position very successfully, similar to the reduction achieved with nitrendipine (20 mg/o.d.), without influencing the pulse rate. Both substances were well tolerated. Carvedilol is an alternative substance for lowering high blood pressure in elderly hypertensive patients.
