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钻石生物电子学

Diamond bio electronics.

作者信息

Linares Robert, Doering Patrick, Linares Bryant

机构信息

Apollo Diamond, Inc., Boston, MA, USA.

出版信息

Stud Health Technol Inform. 2009;149:284-96.

Abstract

The use of diamond for advanced applications has been the dream of mankind for centuries. Until recently this dream has been realized only in the use of diamond for gemstones and abrasive applications where tons of diamonds are used on an annual basis. Diamond is the material system of choice for many applications, but its use has historically been limited due to the small size, high cost, and inconsistent (and typically poor) quality of available diamond materials until recently. The recent development of high quality, single crystal diamond crystal growth via the Chemical Vapor Deposition (CVD) process has allowed physcists and increasingly scientists in the life science area to think beyond these limitations and envision how diamond may be used in advanced applications ranging from quantum computing, to power generation and molecular imaging, and eventually even diamond nano-bots. Because of diamond's unique properties as a bio-compatible material, better understanding of diamond's quantum effects and a convergence of mass production, semiconductor-like fabrication process, diamond now promises a unique and powerful key to the realization of the bio-electronic devices being envisioned for the new era of medical science. The combination of robust in-the-body diamond based sensors, coupled with smart bio-functionalized diamond devices may lead to diamond being the platform of choice for bio-electronics. This generation of diamond based bio-electronic devices would contribute substantially to ushering in a paradigm shift for medical science, leading to vastly improved patient diagnosis, decrease of drug development costs and risks, and improved effectiveness of drug delivery and gene therapy programs through better timed and more customized solutions.

摘要

几个世纪以来,将钻石用于先进应用一直是人类的梦想。直到最近,这个梦想才在钻石用于宝石和研磨应用方面得以实现,每年有大量钻石用于这些领域。钻石是许多应用的首选材料体系,但直到最近,由于可用钻石材料尺寸小、成本高且质量不一致(通常较差),其应用在历史上一直受到限制。通过化学气相沉积(CVD)工艺实现的高质量单晶钻石晶体生长的最新进展,使物理学家以及生命科学领域越来越多的科学家能够突破这些限制,并设想钻石如何用于从量子计算到发电和分子成像等先进应用,甚至最终用于钻石纳米机器人。由于钻石作为生物相容性材料具有独特的特性,对钻石量子效应的更好理解以及大规模生产与类似半导体制造工艺的融合,现在钻石有望成为实现新时代医学所设想的生物电子器件的独特而强大的关键。坚固的体内钻石基传感器与智能生物功能化钻石器件相结合,可能使钻石成为生物电子学的首选平台。这一代基于钻石的生物电子器件将极大地推动医学科学的范式转变,通过更及时、更定制化的解决方案,大幅改善患者诊断,降低药物开发成本和风险,并提高药物递送和基因治疗计划的有效性。

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