Oktem O, Oktay K
Women's Health Center, Assisted Reproduction Unit Molecular Reproduction and Fertility Preservation Program, American Hospital, Istanbul, Turkey.
Minerva Ginecol. 2009 Aug;61(4):247-52.
For decades it has remained as a central dogma in dogma in reproductive biology that female mammals are born with a set non-renewable number of germ cells in the ovary. Recent revolutionary studies challenged this dogma by showing postnatal oogenesis in the adult ovary. In this review article the formation of primordial germ cells (PGC), the precursors of adult gametocytes beginning from their specification to their migration to prospective gonads will be reviewed with a special emphasis on stem cells studies that obtained gametocytes from germ and non germline stem cells.
几十年来，雌性哺乳动物卵巢中的生殖细胞数量固定且不可再生，这一直是生殖生物学的核心教条。最近的突破性研究表明成年卵巢存在产后卵子发生，对这一教条提出了挑战。在这篇综述文章中，将回顾原始生殖细胞（PGC）的形成过程，即成年配子细胞的前体从其特化到迁移至预期性腺的过程，并特别强调从生殖干细胞和非生殖系干细胞获得配子细胞的干细胞研究。
