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NPY 对骨重塑的调节。

NPY regulation of bone remodelling.

机构信息

Neuroscience Research Program, Garvan Institute of Medical Research, St. Vincent's Hospital, 384 Victoria St, Darlinghurst, Sydney, NSW 2010, Australia.

出版信息

Neuropeptides. 2009 Dec;43(6):457-63. doi: 10.1016/j.npep.2009.08.006. Epub 2009 Sep 11.

Abstract

Neuropeptide Y (NPY), a classic neuronal regulator of energy homeostasis, is now also known to be involved in the control of bone homeostasis. Of the five known Y receptors through which the NPY family of ligands signals, the Y1 and Y2 receptors have so far been implicated in the control of osteoblast activity and thus bone formation. Analysis of brain specific NPY overexpressing and Y receptor knockout models has revealed a powerful anabolic pathway likely involving hypothalamic Y2 receptors and osteoblastic Y1 receptors. Furthering our understanding of the mechanisms underlying the involvement of the NPY system in the control of bone could lead to the development of therapies to improve bone mass in patients with diseases such as osteoporosis.

摘要

神经肽 Y(NPY)是一种经典的神经元能量平衡调节剂,现在也被认为参与了骨平衡的控制。在已知的五种 NPY 家族配体信号转导的 Y 受体中,Y1 和 Y2 受体迄今被认为与成骨细胞活性的控制有关,从而影响骨形成。对大脑特异性 NPY 过表达和 Y 受体敲除模型的分析揭示了一种强大的合成代谢途径,可能涉及下丘脑 Y2 受体和成骨细胞 Y1 受体。进一步了解 NPY 系统参与骨控制的机制可能会导致开发治疗骨质疏松症等疾病患者骨量减少的疗法。

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