The Third Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China.
Department of Nephrology, Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine, Shenzhen, China.
Front Endocrinol (Lausanne). 2022 Aug 2;13:908043. doi: 10.3389/fendo.2022.908043. eCollection 2022.
Osteoporosis is a common bone metabolic disease among the middle-aged and elderly, with its high incidence rate and a major cause of disability and mortality. Early studies found that bone metabolic homeostasis is achieved through osteogenesis-osteoclast coupling. Although current anti-osteoporosis drugs can attenuate bone loss caused by aging, they present specific side effects. With the discovery of CD31 Emcn blood vessels in 2014, the effect of H-type blood vessels on bone metabolism has been valued by researchers, and the ternary regulation theory of bone metabolism of "Angiogenesis-Osteoclast-Osteogenesis" has also been recognized. Nowadays, more studies have confirmed that peripheral nerves substantially impact bone metabolism. However, due to the complex function of peripheral nerves, the crosstalk mechanism of "Peripheral nerve-Angiogenesis-Osteoclast-Osteogenesis" has not yet been fully revealed. Neuropeptide serves as signaling molecules secreted by peripheral nerves that regulate blood vessels, osteoblasts, and osteoclasts' functions. It is likely to be the breakthrough point of the quaternary regulation theory of "Peripheral nerve-Angiogenesis-Osteoclast-Osteogenesis". Here, we discuss the effect of peripheral nerves on osteoporosis based on neuropeptides.
骨质疏松症是中老年人常见的骨骼代谢性疾病，其发病率高，是导致残疾和死亡的主要原因之一。早期研究发现，骨骼代谢内稳态是通过成骨细胞-破骨细胞偶联来实现的。尽管目前的抗骨质疏松药物可以减轻衰老引起的骨质流失，但它们存在特定的副作用。2014 年发现 CD31 Emcn 血管后，研究人员开始重视 H 型血管对骨骼代谢的影响，“血管生成-破骨细胞-成骨细胞”的骨骼代谢三元调节理论也得到了认可。如今，越来越多的研究证实，外周神经对骨骼代谢有实质性的影响。然而，由于外周神经的功能复杂，“外周神经-血管生成-破骨细胞-成骨细胞”的串扰机制尚未完全揭示。神经肽作为外周神经分泌的信号分子，调节血管、成骨细胞和破骨细胞的功能，可能成为“外周神经-血管生成-破骨细胞-成骨细胞”四级调节理论的突破点。在这里，我们基于神经肽讨论外周神经对骨质疏松症的影响。
