The University of Kansas, 1530 West 15th St, Rm 3138, Lawrence, KS 66045-7609, United States.
Gait Posture. 2009 Nov;30(4):538-42. doi: 10.1016/j.gaitpost.2009.08.232. Epub 2009 Sep 11.
Current clinical assessments do not adequately detect the onset of postural instability in the early stages of Parkinson's disease (PD). The aim of this study was to identify biomechanical variables that are sensitive to the effects of early Parkinson's disease on the ability to recovery from a balance disturbance. Ten adults diagnosed with idiopathic PD and no clinically detectable postural instability, and ten healthy age-range matched controls (HC) completed the study. The first step in the response to a backwards waist pull was quantified in terms of strategy, temporal, kinematic, kinetic, and center of pressure (COP) variables. People with PD, compared to HC, tended to be less consistent in the choice of stepping limb, utilized more time for weight shift, used a modified ankle joint motion prior to liftoff, and the COP was further posterior at landing. The study results demonstrate that PD changes the response to a balance disturbance which can be quantified using biomechanical variables even before the presence of clinically detectable postural instability. Further studies are required to determine if these variables are sensitive and specific to postural instability.
目前的临床评估不能充分检测到帕金森病（PD）早期姿势不稳定的发生。本研究旨在确定生物力学变量，这些变量对早期帕金森病对从平衡障碍中恢复的能力的影响敏感。十名被诊断患有特发性 PD 且无临床可检测到的姿势不稳定的成年人和十名健康年龄匹配的对照组（HC）完成了这项研究。向后腰部拉动的反应在策略、时间、运动学、动力学和重心（COP）变量方面进行了量化。与 HC 相比，PD 患者在选择踏足肢体时往往不太一致，在体重转移时花费更多的时间，在离地前使用改良的踝关节运动，并且在着陆时 COP 更靠后。研究结果表明，PD 改变了对平衡障碍的反应，即使在存在临床可检测到的姿势不稳定之前，也可以使用生物力学变量对其进行量化。需要进一步的研究来确定这些变量是否对姿势不稳定敏感和特异。
