Krasnianski Michael, Müller T, Zierz S, Winterholler M
Department of Neurology, Martin-Luther-Universität Halle-Wittenberg, Ernst-Grube-Str. 40, 06097 Halle (Saale), Germany.
Eur J Med Res. 2009 Sep 1;14(9):413-4. doi: 10.1186/2047-783x-14-9-413.
The Gasperini syndrome is a very rare brainstem disease characterized by the typical combination of ipsilateral lesions of the cranial nerves V-VII and dissociated contralateral hemihypesthesia, whereas both contralateral and ipsilateral hypacusis was described. Since the first description in 1912, only a few cases of this crossed brainstem syndrome were published so far. Pontine infarction and bleedings were the reported causes of the syndrome. Here we report a 44-year-old man with the classical Gasperini syndrome due to pontine demyelination in multiple sclerosis. The clinical findings were correlated with changes on MRI. The present case shows that classical crossed brainstem syndromes are topological terms not invariably associated with brainstem ischemia in particular vascular areas and may contribute to the differential diagnosis of peripheral facial nerve palsy.
加斯佩里尼综合征是一种非常罕见的脑干疾病，其特征为典型地合并有第Ⅴ-Ⅶ对脑神经同侧损害及对侧分离性半身感觉减退，同时还存在对侧和同侧听力减退的描述。自1912年首次描述以来，迄今为止仅发表了少数几例这种交叉性脑干综合征的病例。脑桥梗死和出血是该综合征的报道病因。在此，我们报告一名44岁男性，因多发性硬化症导致脑桥脱髓鞘而出现典型的加斯佩里尼综合征。临床发现与磁共振成像（MRI）的变化相关。本病例表明，经典的交叉性脑干综合征是拓扑学概念，并非总是与特定血管区域的脑干缺血相关，可能有助于周围性面神经麻痹的鉴别诊断。
