Muranaka Kazuhiro, Ichikawa Satoshi, Matsuda Akira
Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
Nucleic Acids Symp Ser (Oxf). 2009(53):5-6. doi: 10.1093/nass/nrp003.
Synthesis of benzoquinone ansa-adenosines, which are rationally designed as Hsp90 inhibitors by extracting and fusing a natural substrate, ATP, and a natural product, geldanamycin, was described. This simpler scaffold design provides practical synthesis of a set of analogs and demonstrates synthetic innovation.
通过提取并融合天然底物ATP和天然产物格尔德霉素，合理设计作为Hsp90抑制剂的苯醌桥连腺苷的合成方法得到了描述。这种更简单的骨架设计为一系列类似物的实际合成提供了方法，并展示了合成创新。
