氘代苄基腺嘌呤的合成及其作为替代物的应用。
Synthesis of deuterated benzyladenine and its application as a surrogate.
作者信息
Modutlwa Nkaelang, Tada Hiroyuki, Sugahara Yoshiki, Shiraki Koichi, Hara Nobuyuki, Deyashiki Yoshihiro, Ando Takayuki, Maegawa Tomohiro, Monguchi Yasunari, Sajiki Hironao
机构信息
Department of Organic and Medicinal Chemistry, Laboratory of Organic Chemistry, Gifu Pharmaceutical University, Gifu 502-8585, Japan.
出版信息
Nucleic Acids Symp Ser (Oxf). 2009(53):105-6. doi: 10.1093/nass/nrp053.
Palladium on carbon-ethylenediamine complex [Pd/C(en)] catalyzed deuteration of N(6)-benzyladenine-d(5), which is a plant growth regulator, to introduce 5 deuterium atoms, while use of Pd/C as a catalyst led to a complete removal of N(6)-benzyl group. The corresponding deuterated N(6)-benzyladenine was successfully used as a surrogate compound for the quantitative analysis of residual benzyladenine in crops using LC/MS/MS.
碳负载钯-乙二胺配合物[Pd/C(en)]催化植物生长调节剂N(6)-苄基腺嘌呤-d(5)的氘代反应，引入5个氘原子，而使用Pd/C作为催化剂则导致N(6)-苄基完全去除。相应的氘代N(6)-苄基腺嘌呤成功用作替代化合物，用于使用LC/MS/MS对作物中残留苄基腺嘌呤进行定量分析。
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