Oeda Yusuke, Iijima Yoshihiro, Tsunoda Hirosuke, Okubo Akihiro, Seio Kohji, Sekine Mitsuo
Department of Life Science, Graduate School of Bioscience and Technology, Tokyo Institute of Technology, Yokohama 226-8501, Japan.
Nucleic Acids Symp Ser (Oxf). 2009(53):117-8. doi: 10.1093/nass/nrp059.
A variety of 2'-O-arylnucleosides with functional groups were synthesized by the microwave-assisted reaction of 2,2'-anhydrouridine with phenol derivatives. The 2'-O-arylnucleosides thus obtained were incorporated into 2'-O-Me RNA or DNA oligomers and their hybridization properties were studied by T(m) measurements.
通过2,2'-脱水尿苷与酚衍生物的微波辅助反应合成了多种带有官能团的2'-O-芳基核苷。将由此得到的2'-O-芳基核苷掺入2'-O-甲基RNA或DNA寡聚物中，并通过熔点（T(m)）测量研究它们的杂交特性。
