Imai Misaki, Chikatsu Daisuke, Inomata Emire, Oshima Tairo, Kawai Gota
Department of Life and Environmental Sciences, Chiba Institute of Technology, Narashino-shi, Chiba 275-0016, Japan.
Nucleic Acids Symp Ser (Oxf). 2009(53):273-4. doi: 10.1093/nass/nrp137.
Polyamines, especially branched polyamines such as tetrakis(3-aminopropyl)ammonium (Taa), stabilize the tertiary structure of RNA molecules. In this study, we examined the polyamine binding site of the HIV-1 dimerization initiation site (DIS) in the kissing-loop dimer by the docking simulation. It was found that Taa binds predominantly to the kissing loop interaction site of DIS.
多胺，尤其是支链多胺，如四（3-氨丙基）铵（Taa），可稳定RNA分子的三级结构。在本研究中，我们通过对接模拟研究了HIV-1二聚化起始位点（DIS）在亲吻环二聚体中的多胺结合位点。结果发现，Taa主要结合于DIS的亲吻环相互作用位点。
