Brezinschek H P, Wilders-Truschnig M, Leb G, Eber O, Dohr G, Lanzer G, Krejs G J
Department of Internal Medicine, Karl Franzens University, Graz, Austria.
Acta Med Austriaca. 1990;17 Suppl 1:26-7.
In this study a strain of differentiated rat thyroid cells in continuous culture was used to detect the presence of thyroid growth promoting immunoglobulins (TGI) in IgG preparations of serum of patients with endemic and sporadic euthyroid goiters. TGI was detected when FRTL5 cells were used in a mitotic arrest assay by costimulating the cells with IgG and a suboptimal dose of TSH. TGI was present in 65 of 71 endemic goter cases and in 9 of 14 sporadic goiter cases.
在本研究中，使用一株连续培养的分化型大鼠甲状腺细胞，以检测地方性和散发性甲状腺功能正常性甲状腺肿患者血清IgG制剂中促甲状腺生长免疫球蛋白（TGI）的存在。当在有丝分裂停滞试验中使用FRTL5细胞，并用IgG和次优剂量的促甲状腺激素（TSH）共同刺激细胞时，可检测到TGI。71例地方性甲状腺肿病例中有65例存在TGI，14例散发性甲状腺肿病例中有9例存在TGI。
