Sominskiĭ V N, Anshelevich Iu V, Okun' K V
Kardiologiia. 1990 May;30(5):24-8.
Propranolol antihemolytic test parameters calculated with the Hill mathematical model from dose-dependent curves of saturation were studied in 27 patients with myocardial infarction. Erythrocyte beta-adrenoreceptors showed higher sensitivity to propranolol in patients with myocardial infarction within 3 days of the disease. Three weeks after therapy, changes were found in the erythrocyte membranes solely in patients receiving beta-adrenoblockers. The changes are indicative of lower sensitivity of beta-adrenoreceptors to the beta-blocker. Persons with varying responses to propranolol were detected among the patients with myocardial infarction, which may be used to define indications for beta-adrenoblocker therapy.
在27例心肌梗死患者中，研究了用希尔数学模型根据饱和剂量依赖性曲线计算的普萘洛尔抗溶血试验参数。在发病3天内的心肌梗死患者中，红细胞β-肾上腺素能受体对普萘洛尔表现出更高的敏感性。治疗三周后，仅在接受β-肾上腺素能阻滞剂治疗的患者红细胞膜中发现了变化。这些变化表明β-肾上腺素能受体对β-阻滞剂的敏感性降低。在心肌梗死患者中检测到对普萘洛尔反应不同的个体，这可用于确定β-肾上腺素能阻滞剂治疗的适应症。
