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在一般的逐步多重检验程序中霍尔姆程序的最优性。

Optimality of the Holm procedure among general step-down multiple testing procedures.

作者信息

Gordon Alexander Y, Salzman Peter

机构信息

Department of Mathematics and Statistics, University of North Carolina at Charlotte, 9201 University City Blvd, Charlotte, NC 28223, USA; E-mail:

出版信息

Stat Probab Lett. 2008 Sep 15;78(13):1878-1884. doi: 10.1016/j.spl.2008.01.055.

Abstract

We study the class of general step-down multiple testing procedures, which contains the usually considered procedures determined by a nondecreasing sequence of thresholds (we call them threshold step-down, or TSD, procedures) as a parametric subclass. We show that all procedures in this class satisfying the natural condition of monotonicity and controlling the family-wise error rate (FWER) at a prescribed level are dominated by one of them - the classical Holm procedure. This generalizes an earlier result pertaining to the subclass of TSD procedures (Lehmann and Romano, Testing Statistical Hypotheses, 3rd ed., 2005). We also derive a relation between the levels at which a monotone step-down procedure controls the FWER and the generalized FWER (the probability of k or more false rejections).

摘要

我们研究了一般的逐步多重检验程序类,其中包含通常所考虑的由非递减阈值序列确定的程序(我们称它们为阈值逐步下降程序,或TSD程序)作为一个参数子类。我们表明,该类中所有满足单调性自然条件并在规定水平上控制族错误率(FWER)的程序都被其中一个程序——经典的霍尔姆程序所主导。这推广了早期关于TSD程序子类的一个结果(Lehmann和Romano,《检验统计假设》,第3版,2005年)。我们还推导了单调逐步下降程序控制FWER的水平与广义FWER(k个或更多错误拒绝的概率)之间的关系。

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