胎儿脑移植可诱导内侧视前区损伤大鼠的雄性性行为恢复。

Fetal brain transplants induce recovery of male sexual behavior in medial preoptic area-lesioned rats.

作者信息

Paredes R G, Piña A L, Fernández-Ruiz J, Bermúdez-Rattoni F

机构信息

Escuela de Psicología, Universidad Anáhuac, Mexico D.F., Mexico.

出版信息

Brain Res. 1990 Jul 23;523(2):331-6. doi: 10.1016/0006-8993(90)91509-f.

DOI:10.1016/0006-8993(90)91509-f

PMID:1976027

Abstract

Male rats received bilateral lesions within the medial preoptic area which completely abolished sexual behavior. Hypothalamic fetal brain transplants gradually restored sexual behavior to prelesion levels by the 6th week after the transplant. Immunocytochemical analyses revealed tyrosine hydroxylase immunoreactivity neurons within the transplanted tissue. These results demonstrate that fetal brain transplants can restore an innate complex behavior in which no spontaneous recovery is observed.

摘要

雄性大鼠在内侧视前区接受双侧损伤，这完全消除了性行为。下丘脑胎儿脑移植在移植后第6周逐渐将性行为恢复到损伤前水平。免疫细胞化学分析显示移植组织内有酪氨酸羟化酶免疫反应性神经元。这些结果表明，胎儿脑移植可以恢复一种先天的复杂行为，在这种行为中未观察到自发恢复。