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[阿尔及利亚的葡萄糖-6-磷酸脱氢酶缺乏症]

[Glucose-6-phosphate dehydrogenase deficiency in Algeria].

作者信息

Benabadji M, Benlatrache C, Merad F, Suaudeau C, Benmoussa M, Kornprobst G, Cladel G

出版信息

Sem Hop. 1977 Apr 23;53(16):899-904.

PMID:197609
Abstract

The normal level of G6PD activity of the red cells is 6.6 +/- 1.6 i.u/g Hb in men and 6.9 +/- 1.6 i.u./g Hb in women. The histogram of the distribution in the population is not symmetrical. G6PD deficiency is present in Algeria at the national level of 3% (+/- 0.5). The level is less high in the mountainous areas of arab culture, higher in the berber culture and in the Shara. Numerous new variants have been detected in Algeria. The G6PD deficiency predominating in Algeria is of Kabyle type, followed by Laghouat and El-Qued types. Types A-, A+ and Ibaden Austin of negro origin exist in the Sahara population. The Mediterranean type is not found in the Algerian population. The clinical manifestations are rare.

摘要

男性红细胞中葡萄糖-6-磷酸脱氢酶(G6PD)活性的正常水平为6.6±1.6国际单位/克血红蛋白,女性为6.9±1.6国际单位/克血红蛋白。人群中该酶活性分布的直方图不对称。在阿尔及利亚,全国范围内葡萄糖-6-磷酸脱氢酶缺乏症的发生率为3%(±0.5)。在阿拉伯文化的山区该发生率较低,在柏柏尔文化地区和撒哈拉地区较高。在阿尔及利亚已检测到许多新的变异型。阿尔及利亚最常见的葡萄糖-6-磷酸脱氢酶缺乏类型是卡比尔型,其次是拉格瓦特型和埃尔-库德型。撒哈拉地区人群中存在源自黑人的A-、A+和伊巴丹·奥斯汀型。阿尔及利亚人群中未发现地中海型。临床表现较为罕见。

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