Yu Junxiu, Xin Fuze
Department of General Surgery, Liaocheng People's Hospital, 67, West Dongchang Road, Liaocheng, Shandong Province, China 252000.
Hepatogastroenterology. 2009 Jul-Aug;56(93):1219-21.
BACKGROUND/AIMS: To study the association between different histological types and staging of the gastric cancer.
Three hundred and fifty-one patients with gastric cancer and undergone D2 or greater gastrectomy were analyzed retrospectively. The association between TNM stages and histological types, including tubular adenocarcinoma (TUB), poorly differentiated adenocarcinoma (POR), signet-ring cell carcinoma (SIG), mucinous adenocarcinoma (MUC), and undifferentiated carcinoma (UND), were analyzed by univariate and multivariate analysis.
Univariate analysis showed that the prevalence rates of T,M stages of POR, MUC, SIG, UND were not significantly different from that of TUB (all p values > 0.05). The prevalence rates of the N stage of POR, MUC, UND were significantly different from TUB p = 0.002, 0.011, 0.032). The prevalence rates of the N stage of SIG were not significantly different from TUB (p = 0.070). Multivariate analysis indicated that there was no histological type that was influencing factors on the T, M stages of gastric cancer. MUC, SIG, UND were not influencing factors on N stage, but, POR was influencing factor on the N stage (p = 0.011).
There was no association between histological type and TNM stages, except the POR, which has a significant association with the N stage of gastric cancer.
背景/目的：研究胃癌不同组织学类型与分期之间的关联。
回顾性分析351例行D2或更大范围胃切除术的胃癌患者。通过单因素和多因素分析，研究TNM分期与组织学类型之间的关联，组织学类型包括管状腺癌（TUB）、低分化腺癌（POR）、印戒细胞癌（SIG）、黏液腺癌（MUC）和未分化癌（UND）。
单因素分析显示，POR、MUC、SIG、UND的T、M分期患病率与TUB无显著差异（所有p值>0.05）。POR、MUC、UND的N分期患病率与TUB有显著差异（p = 0.002、0.011、0.032）。SIG的N分期患病率与TUB无显著差异（p = 0.070）。多因素分析表明，没有组织学类型是胃癌T、M分期的影响因素。MUC、SIG、UND不是N分期的影响因素，但POR是N分期的影响因素（p = 0.011）。
除POR与胃癌N分期有显著关联外，组织学类型与TNM分期之间无关联。
