Keiser Paul B, Miller Lori B, Biggs-Cicatelli Susan, Zollinger Wendell D
Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD, United States.
Vaccine. 2009 Nov 16;27(49):6809-13. doi: 10.1016/j.vaccine.2009.09.019. Epub 2009 Sep 15.
Several studies have shown plasma fibrinogen increases following some vaccinations, but the specific triggers and the kinetics of this response are not well understood. We conducted a phase I trial of an outer membrane vesicle vaccine for Neisseria meningitidis. Plasma fibrinogen was measured on days 0, 2 and 14 following each of 3 doses. The highest dose of vaccine was associated with the greatest increase in fibrinogen at day 2, which decreased by day 14. The first vaccination caused a greater increase than either subsequent vaccination. These transient increases in fibrinogen are comparable to what occurs with upper respiratory infections and have not been demonstrated to represent an increased risk of adverse vascular events.
多项研究表明，接种某些疫苗后血浆纤维蛋白原会升高，但这种反应的具体触发因素和动力学尚不清楚。我们进行了一项针对脑膜炎奈瑟菌外膜囊泡疫苗的I期试验。在3剂疫苗接种后的第0、2和14天测量血浆纤维蛋白原。最高剂量的疫苗在第2天与纤维蛋白原的最大增加相关，到第14天有所下降。首次接种引起的纤维蛋白原增加比随后的任何一次接种都更大。这些纤维蛋白原的短暂升高与上呼吸道感染时的情况相当，尚未证明代表不良血管事件风险增加。
