Neuhaus Herbert, Hollemann Thomas
Institut für Physiologische Chemie, Halle/S., Germany.
Gene Expr Patterns. 2009 Dec;9(8):568-71. doi: 10.1016/j.gep.2009.09.002. Epub 2009 Sep 15.
Here we report the cloning and expression of chick TPTE, the avian ortholog of the mammalian pTEN2 gene. In the chick embryo, cTPTE expression begins at HH (Hamburger and Hamilton) stage 18 and is restricted to the tubular structures of the developing kidney. In the mesonephros, cTPTE expression localizes to the proximal tubules. In the adult kidney cTPTE expression is no longer detectable. The data presented here suggest that cTPTE plays an important role in the regulation of embryonic kidney function.
在此，我们报告了鸡TPTE（哺乳动物pTEN2基因的禽类直系同源基因）的克隆与表达。在鸡胚胎中，cTPTE表达于HH（汉堡和汉密尔顿）第18阶段开始，并局限于发育中肾脏的管状结构。在中肾中，cTPTE表达定位于近端小管。在成年肾脏中，不再能检测到cTPTE的表达。此处呈现的数据表明，cTPTE在胚胎肾功能的调节中发挥重要作用。
