药物对孕中期母血清筛查的影响。
Medication effects on midtrimester maternal serum screening.
作者信息
Pekarek Dawn M, Chapman Victoria R, Neely Cherry L, Ramsey Patrick S, Biggio Joseph R
机构信息
Center for Women's Reproductive Health, University of Alabama at Birmingham, Birmingham, AL, USA.
出版信息
Am J Obstet Gynecol. 2009 Dec;201(6):622.e1-5. doi: 10.1016/j.ajog.2009.07.013. Epub 2009 Sep 17.
OBJECTIVE
To determine whether medication classes are associated with alterations in concentrations of Quad screen analytes or the screen-positive rate.
STUDY DESIGN
We conducted a retrospective cohort study of women with singleton gestations who received prenatal care and had a Quad screen performed in the University of Alabama at Birmingham system. Information on prescription medications was abstracted. Mean multiples of the medians for each analyte (alpha-fetoprotein, estriol, human chorionic gonadotropin, and inhibin A) and overall screening results were compared between those taking the class of medication and controls not taking any medications.
RESULTS
There were 6206 women evaluated; 1337 took at least 1 prescription medicine and 4869 were controls. Mean analyte multiples of the medians were significantly different in women taking some medications compared with controls. Women taking certain medications had an increased screen-positive rate.
CONCLUSION
Medications taken around the time of maternal serum screening are associated with alterations in individual analyte multiples of the medians, as well as the screen-positive rates.
目的
确定药物类别是否与四联筛查分析物浓度的改变或筛查阳性率相关。
研究设计
我们对在阿拉巴马大学伯明翰分校系统接受产前护理并进行了四联筛查的单胎妊娠女性进行了一项回顾性队列研究。提取了关于处方药的信息。比较了服用该类药物的女性与未服用任何药物的对照组中每种分析物（甲胎蛋白、雌三醇、人绒毛膜促性腺激素和抑制素A）的中位数倍数均值以及总体筛查结果。
结果
共评估了6206名女性；1337名服用了至少1种处方药，4869名作为对照组。与对照组相比，服用某些药物的女性分析物中位数倍数均值有显著差异。服用某些药物的女性筛查阳性率升高。
结论
孕期血清筛查前后服用的药物与各分析物中位数倍数的改变以及筛查阳性率相关。
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