Walt R P
Department of Medicine, Queen Elizabeth Hospital, Birmingham, U.K.
Scand J Gastroenterol Suppl. 1990;174:29-36. doi: 10.3109/00365529009091927.
The expectation that prostaglandin analogues would improve the ulcer healing abilities of other agents by combining mucosal protection with decreased acid secretion has been proved unwarranted. The ulcer healing capabilities of these drugs reflect their antisecretory potency. A role for these drugs in ulcer healing is questionable but their use has been advocated most strongly to prevent ulceration developing during treatment with non-steroidal anti-inflammatory drugs. While some evidence supports this role, an important clinical benefit of reducing complication rates has yet to be demonstrated.
前列腺素类似物通过结合黏膜保护和减少胃酸分泌来提高其他药物溃疡愈合能力的期望已被证明是没有根据的。这些药物的溃疡愈合能力反映了它们的抗分泌效力。这些药物在溃疡愈合中的作用值得怀疑，但最强烈主张使用它们是为了预防在用非甾体抗炎药治疗期间发生溃疡。虽然一些证据支持这一作用，但降低并发症发生率的重要临床益处尚未得到证实。
