Craig John J, Hunt Stephen J
Royal Group of Hospitals, Grosvenor Road, Belfast, UK.
Pract Neurol. 2009 Oct;9(5):268-77. doi: 10.1136/jnnp.2009.187898.
Epilepsy has special implications for women, especially during their childbearing years, and particularly when pregnancy is contemplated. Being aware of the relevant issues is therefore essential. For anyone with juvenile myoclonic epilepsy and other idiopathic generalised epilepsies, valproate is generally regarded as the gold standard treatment against which other antiepileptic drugs are compared. However, information from pregnancy registers consistently show valproate to be associated with the highest risk for major congenital malformations, and studies exploring cognitive and behavioural development of offspring also show that valproate has an adverse impact. This creates a significant headache when trying to choose the "right" drug for most women with a generalised epilepsy syndrome.
癫痫对女性有特殊影响，尤其是在育龄期，特别是在考虑怀孕时。因此，了解相关问题至关重要。对于任何患有青少年肌阵挛癫痫和其他特发性全身性癫痫的人来说，丙戊酸盐通常被视为其他抗癫痫药物与之比较的金标准治疗药物。然而，来自妊娠登记处的信息始终表明，丙戊酸盐与重大先天性畸形的最高风险相关，并且探索后代认知和行为发育的研究也表明丙戊酸盐有不利影响。当试图为大多数患有全身性癫痫综合征的女性选择“正确”药物时，这会造成很大的困扰。
