Amato A A, Barohn R J
Department of Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA.
J Neurol Neurosurg Psychiatry. 2009 Oct;80(10):1060-8. doi: 10.1136/jnnp.2008.169375.
The major types of idiopathic inflammatory myopathy include dermatomyositis (DM), polymyositis (PM), inclusion body myositis (IBM) and immune mediated necrotising myopathy (NM). These myositides appear clinically, histologically and pathogenically distinct. DM, PM and immune mediated NM are responsive to immunosuppressive therapy, in contrast with IBM which is generally refractory to therapy. Greater understanding of the pathogenic bases of these disorders should hopefully lead to better treatment. We need well designed, prospective, double blind, placebo controlled trials in order to determine the best therapeutic options for these different disorders.
特发性炎性肌病的主要类型包括皮肌炎（DM）、多发性肌炎（PM）、包涵体肌炎（IBM）和免疫介导坏死性肌病（NM）。这些肌炎在临床、组织学和发病机制上表现各异。与通常对治疗难治的IBM不同，DM、PM和免疫介导的NM对免疫抑制治疗有反应。对这些疾病发病机制基础的更深入了解有望带来更好的治疗效果。我们需要设计良好的前瞻性、双盲、安慰剂对照试验，以确定针对这些不同疾病的最佳治疗方案。
