Li Li-Juan, Li Hong-Xia, Wu Xin-Tong, Yan Bo, Zhou Dong
Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2009 Jul;40(4):604-7.
To investigate the effect of geniposide on vascular dementia (VaD) in rats.
VaD rat model was established by permanent ligation of bilateral common carotid arteries. Morris water maze performance was assessed after 4 weeks of treatment with geniposide, followed by pathological examinations of hippocampus and cerebral cortex.
The VaD rats had significantly longer escape latency and lower percentage of activities in platform quadrant than the rats in the sham surgery group (P<0.05). The VaD rats treated with geniposide [50 mg/(kg x d), 75 mg/(kg x d)] had significantly shorter escape latency (except the first day of the test) and significantly higher percentage of activities in platform quadrant than the VaD rats without treatment (P<0.05). No significant differences were found between the geniposide treated group and the Donepezil treated group and the sham surgery control group. Geniposide significantly alleviated neurons,apoptosis and necrosis induced by chronic cerebral hypoperfusion of cortex and hippocampus.
Chronic cerebral hypoperfusion can induce cognitive impairment. Geniposide can improve cognitive ability of Vascular Dementia in rats. This may represent a potential treatment strategy for vascular dementia.
探讨栀子苷对大鼠血管性痴呆（VaD）的影响。
通过永久性结扎双侧颈总动脉建立VaD大鼠模型。用栀子苷治疗4周后评估Morris水迷宫实验表现，随后对海马和大脑皮层进行病理检查。
与假手术组大鼠相比，VaD大鼠的逃避潜伏期显著延长，在平台象限的活动百分比降低（P<0.05）。用栀子苷[50mg/(kg·d)，75mg/(kg·d)]治疗的VaD大鼠的逃避潜伏期显著缩短（测试第一天除外），在平台象限的活动百分比显著高于未治疗的VaD大鼠（P<0.05）。栀子苷治疗组与多奈哌齐治疗组及假手术对照组之间未发现显著差异。栀子苷显著减轻了慢性脑灌注不足诱导的皮层和海马神经元凋亡及坏死。
慢性脑灌注不足可导致认知障碍。栀子苷可改善大鼠血管性痴呆的认知能力。这可能代表了一种治疗血管性痴呆的潜在策略。
