Ossareh S, Naseem S, Faraji M A, Bahrami Asl M, Yousefnejad A
Department of Internal Medicine, Nephrology Ward, Hasheminejad Kidney Center, Iran University of Medical Sciences, Tehran, Iran.
Transplant Proc. 2009 Sep;41(7):2814-6. doi: 10.1016/j.transproceed.2009.07.054.
Posttransplant diabetes mellitus (PTDM) is a frequent complication of renal transplantation. This study was performed to determine the prevalence of and risk factors for PTDM among Iranian renal transplant recipients. In this cross-sectional study, 300 patients were studied in 2007. It included questionnaires with clinical data and blood samples. PTDM was defined as DM without a pretransplant history. The 184 (61.3%) male and 116 (38.7%) female patients of overall mean age of 41.2 +/- 13.5 years were 67.4 +/- 48.6 months after the procedure. PTDM was observed in 24 patients (8%). The mean interval to develop PTDM was 19.9 +/- 31.5 months. The mean age of PTDM patients was significantly higher than non-PTDM patients: 49.4 +/- 13.4 vs 40.6 +/- 13.4 years (P < .005). The mean serum high-density lipoprotein (HDL) was higher among PTDM compared with non-PTDM patients: 71.4 +/- 21 vs 58.6 +/- 14.6 (P < .005). There was a trend toward higher serum low-density lipoprotein (LDL) among PTDM patients: 109.2 +/- 29.5 vs 96.2 +/- 25.2 (P = .06). A recent admission was more frequent among PTDM patients (58.3% vs 28.7%; P < .005), as was history of hepatitis C virus (HCV) infection (6% vs 1%; P < .01). There was no significant difference in doses of immunosuppressive drugs and doses atenolol, mean body mass index, DM family history, rejection, cytomegalovirus (CMV) infection, or frequency of positive anti-HCV antibody between the 2 groups. Our study showed an 8% prevalence of PTDM. Mean age, history of recent admissions and HCV infection, as well as mean plasma HDL and LDL levels were higher among PTDM patients.
移植后糖尿病（PTDM）是肾移植常见的并发症。本研究旨在确定伊朗肾移植受者中PTDM的患病率及危险因素。在这项横断面研究中，2007年对300例患者进行了研究。研究内容包括临床数据问卷和血样采集。PTDM定义为移植前无糖尿病病史的糖尿病。184例（61.3%）男性和116例（38.7%）女性患者，总体平均年龄为41.2±13.5岁，术后67.4±48.6个月。24例患者（8%）出现PTDM。发生PTDM的平均间隔时间为19.9±31.5个月。PTDM患者的平均年龄显著高于非PTDM患者：49.4±13.4岁 vs 40.6±13.
