肺癌小鼠模型中的免疫反应模拟人类抗Hu反应性。
Immune response in lung cancer mouse model mimics human anti-Hu reactivity.
作者信息
Kazarian Meleeneh, Calbo Joaquim, Proost Natalie, Carpenter Catherine L, Berns Anton, Laird-Offringa Ite A
机构信息
Departments of Surgery and of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California/Norris Cancer Center, 1441 Eastlake Ave. NOR 6420, Norris Cancer Center, Los Angeles, CA 90089, United States.
出版信息
J Neuroimmunol. 2009 Dec 10;217(1-2):38-45. doi: 10.1016/j.jneuroim.2009.08.014. Epub 2009 Sep 17.
Abstract
Most patients with paraneoplastic encephalomyelitis/sensory neuronopathy PEM/SN have small-cell lung cancer (SCLC) and develop antibodies against neuronal-specific Hu proteins, which are abnormally expressed in the tumor. Anti-Hu reactivity is present in ~16% of SCLC patients without PEM/SN. Here we test the hypothesis that engineered SCLC-prone mice may exhibit anti-Hu reactivity. We show that tumors from SCLC-prone mice misexpress Hu proteins, and 14% of mice harbor anti-Hu antibodies. Mice appear to show reactivity prior to clinical diagnosis of SCLC. This mouse model system will be useful to study SCLC-associated autoimmunity, its diagnostic value, and the potential protective role of oncoantigen-directed autoantibodies.
摘要
大多数副肿瘤性脑脊髓炎/感觉神经元病（PEM/SN）患者患有小细胞肺癌（SCLC），并产生针对神经元特异性Hu蛋白的抗体，这些蛋白在肿瘤中异常表达。在无PEM/SN的SCLC患者中，约16%存在抗Hu反应性。在此，我们检验了一个假说，即易患SCLC的工程小鼠可能会出现抗Hu反应性。我们发现，易患SCLC的小鼠的肿瘤会错误表达Hu蛋白，且14%的小鼠携带抗Hu抗体。小鼠似乎在SCLC临床诊断之前就表现出反应性。这个小鼠模型系统将有助于研究与SCLC相关的自身免疫、其诊断价值以及肿瘤抗原导向的自身抗体的潜在保护作用。
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