University of Pittsburgh Medical Center, Mercy Hospital, Department of Laboratory medicine, 1400 Locust street, Pittsburgh, PA 15219, USA.
Pathol Res Pract. 2009;205(12):807-10. doi: 10.1016/j.prp.2009.07.016. Epub 2009 Sep 19.
Micropapillary carcinoma is a rare distinct variant of high grade urothelial carcinoma, which has specific morphological characteristics and is almost always associated with muscularis propria and vascular invasion. No currently defined imaging techniques can reliably diagnose some types of deeply invasive urothelial carcinoma of urinary bladder, in particular its micropapillary variant. Therefore, the pathological findings are crucial in making the diagnosis. Micropapillary carcinoma (MPC) is a tumor with an aggressive clinical course, an advanced stage of disease at the time of presentation, and usually a poor outcome. Metastatic micropapillary carcinoma to bladder should always be included in the differential diagnosis. Correct histological diagnosis of this aggressive neoplasm would allow timely, albeit intense, radical treatment of the disease. The current most generally favored treatment option for all patients who present with MPC is immediate radical cystectomy.
微乳头癌是高级别尿路上皮癌的一种罕见的特殊类型，具有特定的形态学特征，几乎总是与固有肌层和血管浸润相关。目前尚无明确的影像学技术可以可靠地诊断某些类型的浸润性膀胱癌，尤其是其微乳头型。因此，病理发现对诊断至关重要。微乳头癌（MPC）是一种具有侵袭性临床病程的肿瘤，在出现时疾病已处于晚期，且通常预后较差。转移性微乳头癌至膀胱应始终纳入鉴别诊断。对这种侵袭性肿瘤的正确组织学诊断将允许及时但强烈的根治性治疗。目前对于所有出现 MPC 的患者，最常用的治疗选择是立即进行根治性膀胱切除术。
