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为一组解剖学上逼真的参考怀孕女性模型推导的内部电子发射体的比吸收分数。

Specific absorbed fractions for internal electron emitters derived for a set of anatomically realistic reference pregnant female models.

作者信息

Guo Bingqi, Xu X George, Shi Chengyu

机构信息

Radiation Oncology, University of Texas Health Science Center at San Antonio, Ste G240, San Antonio, TX 78229, USA.

出版信息

Radiat Prot Dosimetry. 2010 Jan;138(1):20-8. doi: 10.1093/rpd/ncp182. Epub 2009 Sep 18.

DOI:10.1093/rpd/ncp182
PMID:19767604
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2909795/
Abstract

The specific absorbed fraction (Phi), defined by the Medical Internal Radiation Dose Committee, is generally applied to evaluate the average absorbed dose in a target organ as a result of radioactive materials deposited in a source organ. This paper reports a new set of Phi values for internal electron emitters ranging from 10 keV to 4 MeV from various internal organs of the mother to the fetus based on three newly developed pregnant female tomographic models, called RPI-P3, RPI-P6 and RPI-P9. The results show a linear log relationship between Phi values and electron energy. The linear log coefficients have been derived and reported. The relationship between Phi values and mean distances between source organs and the fetus were also determined to allow for individual dosimetry. Since the RPI-P models have finer details of human anatomy and more realistic organ volumes and geometries, which follow the latest ICRP reference values, the newly derived Phi values could be used as reference values in determination of the dose to the fetus from internal electron emitters.

摘要

由医学内照射剂量委员会定义的比吸收分数(Phi),通常用于评估源器官中沉积的放射性物质在靶器官中产生的平均吸收剂量。本文基于新开发的三种孕妇断层模型,即RPI-P3、RPI-P6和RPI-P9,报告了从母亲各内部器官到胎儿的10 keV至4 MeV范围内的内电子发射体的一组新的Phi值。结果表明,Phi值与电子能量之间存在线性对数关系。已推导并报告了线性对数系数。还确定了Phi值与源器官和胎儿之间平均距离的关系,以进行个体剂量测定。由于RPI-P模型具有更精细的人体解剖细节、更符合实际的器官体积和几何形状,且遵循国际辐射防护委员会(ICRP)的最新参考值,因此新推导的Phi值可作为确定内电子发射体对胎儿剂量的参考值。

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本文引用的文献

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SAF values for internal photon emitters calculated for the RPI-P pregnant-female models using Monte Carlo methods.使用蒙特卡罗方法为RPI-P怀孕女性模型计算的内部光子发射体的SAF值。
Med Phys. 2008 Jul;35(7):3215-24. doi: 10.1118/1.2936414.
2
Kinetic modeling in support of radionuclide dose assessment.支持放射性核素剂量评估的动力学建模。
Semin Nucl Med. 2008 Sep;38(5):335-46. doi: 10.1053/j.semnuclmed.2008.05.007.
3
Fluence to absorbed foetal dose conversion coefficients for photons in 50 keV-10 GeV calculated using RPI-P models.使用RPI - P模型计算的50 keV至10 GeV光子的注量到胎儿吸收剂量转换系数。
Radiat Prot Dosimetry. 2008;131(2):159-66. doi: 10.1093/rpd/ncn163. Epub 2008 Jun 2.
4
Fluence-to-absorbed dose conversion coefficients for use in radiological protection of embryo and foetus against external exposure to electrons from 10 MeV TO 10 GeV.用于胚胎和胎儿放射防护以抵御10 MeV至10 GeV电子外照射的注量-吸收剂量转换系数。
Health Phys. 2008 Apr;94(4):313-7. doi: 10.1097/01.HP.0000295555.47192.d1.
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Fluence-to-absorbed-dose conversion coefficients for neutron beams from 0.001 eV to 100 GeV calculated for a set of pregnant female and fetus models.针对一组怀孕女性和胎儿模型计算的能量范围从0.001电子伏特至100吉电子伏特的中子束注量到吸收剂量转换系数。
Phys Med Biol. 2008 Mar 7;53(5):1425-46. doi: 10.1088/0031-9155/53/5/017. Epub 2008 Feb 19.
6
A boundary-representation method for designing whole-body radiation dosimetry models: pregnant females at the ends of three gestational periods--RPI-P3, -P6 and -P9.一种用于设计全身辐射剂量测定模型的边界表示方法:处于三个妊娠期末期的孕妇——RPI-P3、-P6和-P9。
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