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Comment on 'Estimating a modified Grubb's exponent in healthy human brains with near infrared spectroscopy and transcranial Doppler'.评论“应用近红外光谱和经颅多普勒技术评估健康人脑的改良 Grubb's 指数”一文。
Physiol Meas. 2009 Oct;30(10):L9-L11; author reply L13-L14. doi: 10.1088/0967-3334/30/10/L01. Epub 2009 Sep 18.
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本文引用的文献

1
Estimating a modified Grubb's exponent in healthy human brains with near infrared spectroscopy and transcranial Doppler.使用近红外光谱和经颅多普勒估计健康人脑的修正格拉布斯指数。
Physiol Meas. 2009 Jan;30(1):1-12. doi: 10.1088/0967-3334/30/1/001. Epub 2008 Nov 27.
2
A multicompartment vascular model for inferring baseline and functional changes in cerebral oxygen metabolism and arterial dilation.一种用于推断脑氧代谢和动脉扩张的基线及功能变化的多室血管模型。
J Cereb Blood Flow Metab. 2007 Jun;27(6):1262-79. doi: 10.1038/sj.jcbfm.9600435. Epub 2007 Jan 3.
3
Linear and nonlinear relationships between neuronal activity, oxygen metabolism, and hemodynamic responses.神经元活动、氧代谢和血流动力学反应之间的线性与非线性关系。
Neuron. 2004 Apr 22;42(2):347-55. doi: 10.1016/s0896-6273(04)00221-1.
4
Can the cerebral metabolic rate of oxygen be estimated with near-infrared spectroscopy?能否用近红外光谱法估算大脑的氧代谢率？
Phys Med Biol. 2003 Aug 7;48(15):2405-18. doi: 10.1088/0031-9155/48/15/311.
5
Changes in human cerebral blood flow and cerebral blood volume during hypercapnia and hypocapnia measured by positron emission tomography.通过正电子发射断层扫描测量高碳酸血症和低碳酸血症期间人脑血流量和脑血容量的变化。
J Cereb Blood Flow Metab. 2003 Jun;23(6):665-70. doi: 10.1097/01.WCB.0000067721.64998.F5.
6
Concurrent optical imaging spectroscopy and laser-Doppler flowmetry: the relationship between blood flow, oxygenation, and volume in rodent barrel cortex.同步光学成像光谱与激光多普勒血流测量：啮齿动物桶状皮层中血流、氧合作用与容积之间的关系。
Neuroimage. 2001 Jun;13(6 Pt 1):1002-15. doi: 10.1006/nimg.2001.0808.
7
Increased oxygen consumption following activation of brain: theoretical footnotes using spectroscopic data from barrel cortex.大脑激活后耗氧量增加：使用桶状皮层光谱数据的理论注释
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8
Relative changes of cerebral arterial and venous blood volumes during increased cerebral blood flow: implications for BOLD fMRI.脑血流量增加时脑动脉和静脉血容量的相对变化：对血氧水平依赖性功能磁共振成像的影响
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Calibrated functional MRI: mapping the dynamics of oxidative metabolism.校准功能磁共振成像：绘制氧化代谢动力学图谱
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The effects of changes in PaCO2 on cerebral blood volume, blood flow, and vascular mean transit time.动脉血二氧化碳分压（PaCO2）变化对脑血容量、脑血流量及血管平均通过时间的影响。
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评论“应用近红外光谱和经颅多普勒技术评估健康人脑的改良 Grubb's 指数”一文。

Comment on 'Estimating a modified Grubb's exponent in healthy human brains with near infrared spectroscopy and transcranial Doppler'.

出版信息

Physiol Meas. 2009 Oct;30(10):L9-L11; author reply L13-L14. doi: 10.1088/0967-3334/30/10/L01. Epub 2009 Sep 18.

DOI:10.1088/0967-3334/30/10/L01
PMID:19767672
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6487489/
Abstract

The relationship between cerebral blood volume (CBV) and blood flow (CBF) has gained widespread interest because of its utility in using functional magnetic resonance imaging and optical imaging methods to estimate the cerebral metabolic rate of oxygen (CMRO(2)). A recent paper by Leung et al (2009 Physiol. Meas. 30 1-12) nicely presents measurements relating CBV to cerebral blood flow velocity (CBFV) as measured by near infrared spectroscopy and transcranial Doppler, respectively. They suggest that this relationship cannot be inverted to estimate CBF (or CBFV) from CBV, and that doing so to estimate CMRO(2) is inappropriate. We argue that these data, and other related published data, do permit the estimation of CBF from CBV and thus enable CMRO(2) to be estimated when only measures of CBV and deoxygenated hemoglobin are available.

摘要

脑血容量 (CBV) 和血流 (CBF) 之间的关系引起了广泛的关注，因为它可以利用功能磁共振成像和光学成像方法来估计脑氧代谢率 (CMRO(2))。最近，Leung 等人（2009 年《生理学测量》第 30 卷 1-12 页）发表的一篇论文很好地介绍了通过近红外光谱和经颅多普勒分别测量 CBV 与脑血流速度 (CBFV) 之间的关系。他们认为，不能通过这种关系从 CBV 反推来估计 CBF（或 CBFV），而且从 CBV 来估计 CMRO(2)是不合适的。我们认为，这些数据以及其他相关的已发表数据确实允许从 CBV 估计 CBF，从而在仅测量 CBV 和去氧血红蛋白的情况下能够估计 CMRO(2)。