Hanada K, Akita N, Hashimoto I
Department of Dermatology, Hirosaki University School of Medicine.
Nihon Hifuka Gakkai Zasshi. 1990 Jun;100(7):757-60.
To estimate the pathogenesis of magnesium deficiency dermatitis (MDD) in the hairless rats fed with a hypomagnesic diet, plasma concentrations of leukotrienes (LTB4, LTC4, LTD4) were measured. Inhibitory effect of azelastine hydrochloride (AZ), which is known as an inhibitor of 5-lipoxygenase, on MDD was also evaluated. In the hairless rats with magnesium deficiency condition, plasma level of leukotriene B4 was increased, whereas LTC4 and LTD4 showed no changes. In AZ-administered rats, MDD was depressed with the dose-dependent tendency. However, the decrease of LTB4 level did not follow therapeutic effect of AZ for gross appearance of dermatitis. These results indicated that development of MDD associates with increase of LTB4, but its pathogenetic role still remains unknown, and inhibitory effect of AZ against MDD not based on reduction of LTB4 production.
为评估喂食低镁饮食的无毛大鼠中镁缺乏性皮炎（MDD）的发病机制，检测了血浆中白三烯（LTB4、LTC4、LTD4）的浓度。还评估了作为5-脂氧合酶抑制剂的盐酸氮卓斯汀（AZ）对MDD的抑制作用。在处于镁缺乏状态的无毛大鼠中，白三烯B4的血浆水平升高，而LTC4和LTD4无变化。在给予AZ的大鼠中，MDD呈剂量依赖性减轻。然而，LTB4水平的降低并未伴随AZ对皮炎总体外观的治疗效果。这些结果表明，MDD的发生与LTB4的增加有关，但其致病作用仍不清楚，且AZ对MDD的抑制作用并非基于LTB4生成的减少。
