Tominaga Kazunari, Ochi Masahiro, Watanabe Toshio, Fujiwara Yasuhiro, Arakawa Tetsuo
Department of Gastroenterology, Osaka City University Graduate School of Medicine.
Nihon Rinsho. 2009 Sep;67(9):1731-40.
Functional gastrointestinal disorders (FGIDs) such as functional dyspepsia (FD) and irritable bowel syndrome (IBS) are included in functional somatic syndromes (FSS), which are designated as medically unexplained physical symptoms. Pathopysiology of these diseases are characterized by multi-functional disorders of the gastrointestinal (GI) tract including psychosomatic sensation, brain-gut interaction, autonomic nervous systems, motility disorders, local inflammation, and visceral perception. However, the standard therapy for these diseases is not established, since predominant factors among them associated with respective patients are difficult to be identified in a clinical field. In this section, we are going to present the accumulating evidences for the pathophysiology and therapeutic strategy of FD and IBS.
功能性胃肠疾病（FGIDs），如功能性消化不良（FD）和肠易激综合征（IBS），属于功能性躯体综合征（FSS），后者被定义为医学上无法解释的躯体症状。这些疾病的病理生理学特征是胃肠道（GI）的多功能紊乱，包括身心感觉、脑肠相互作用、自主神经系统、动力障碍、局部炎症和内脏感觉。然而，这些疾病的标准治疗方法尚未确立，因为在临床领域很难确定与各个患者相关的主要因素。在本节中，我们将介绍关于FD和IBS病理生理学及治疗策略的越来越多的证据。
