Centre for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
Clin Microbiol Infect. 2010 Aug;16(8):1155-8. doi: 10.1111/j.1469-0691.2009.03058.x. Epub 2009 Sep 21.
Extracellular adherence protein (Eap) from Staphylococcus aureus has been reported to have strong anti-inflammatory properties, which make Eap a potential anti-inflammatory agent. However, Eap has also been demonstrated to trigger T-cell activation and to share structural homology with superantigens. In this study, we focused on whether Eap fulfilled the definition criteria for a superantigen. We demonstrate that T-cell activation by Eap is dependent on both major histocompatibility complex class II and intercellular adhesion molecule type 1, that cellular processing is required for Eap to elicit T-cell proliferation, and that the kinetics of proliferation resemble the profile of a conventional antigen and not that of a superantigen.
金黄色葡萄球菌的细胞外黏附蛋白 (Eap) 具有很强的抗炎特性，这使其成为一种有潜力的抗炎药物。然而，Eap 也已被证明可触发 T 细胞活化，并与超抗原具有结构同源性。在本研究中，我们专注于 Eap 是否符合超抗原的定义标准。我们证明 Eap 诱导 T 细胞活化既依赖于主要组织相容性复合体 II 类，也依赖于细胞间黏附分子 1，细胞处理是 Eap 引发 T 细胞增殖所必需的，且增殖动力学类似于常规抗原而非超抗原的特征。
