Okada Atsushi, Sasaki Shoichi, Fujiyoshi Yukio, Niimi Kazuhiro, Kurokawa Satoshi, Umemoto Yukihiro, Kohri Kenjiro
Department of Nephro-urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan.
Int J Urol. 2009 Sep;16(9):765-7. doi: 10.1111/j.1442-2042.2009.02336.x.
Papillary renal cell carcinomas (RCC) are the second most frequently identified pathological subtypes of RCC. Occasionally, papillary RCC demonstrate pathological characteristics of renal oncocytomas (RO), benign renal tumors. We report the case of an 81-year-old woman with an oncocytic papillary RCC, which was difficult to differentiate from a hybrid of RO and papillary RCC, who underwent left radical nephrectomy. Morphological examination showed oncocytic tumor region and partially scattered regions with papillary structure. Immunohistochemical examinations demonstrated strongly positive staining of alpha-methylacyl-CoA racemase in the papillary region and negative staining of progesterone receptor and CD117 in both regions. Fluorescence in situ hybridization confirmed the increased number of copies of chromosome 7 in the papillary region. Comprehensively, this case could be diagnosed as oncocytic papillary RCC. No evidence of disease recurrence was found at 12 months' follow up.
乳头状肾细胞癌（RCC）是RCC中第二常见的病理亚型。偶尔，乳头状RCC表现出肾嗜酸细胞瘤（RO）（一种良性肾肿瘤）的病理特征。我们报告了一例81岁患有嗜酸细胞性乳头状RCC的女性病例，该病例难以与RO和乳头状RCC的混合型相鉴别，患者接受了左肾根治性切除术。形态学检查显示嗜酸细胞瘤区域以及部分散在的乳头状结构区域。免疫组织化学检查显示乳头状区域α-甲基酰基辅酶A消旋酶染色强阳性，两个区域孕酮受体和CD117染色均为阴性。荧光原位杂交证实乳头状区域7号染色体拷贝数增加。综合来看，该病例可诊断为嗜酸细胞性乳头状RCC。随访12个月未发现疾病复发迹象。
