Lynde Charles W, Poulin Yves, Guenther Lyn, Jackson Christine
Centre for Dermatology, Markham, ON.
J Cutan Med Surg. 2009 Sep-Oct;13(5):235-52. doi: 10.2310/7750.2009.08071.
Although some data addressing the burden of illness associated with psoriasis and psoriatic arthritis (PsA) have been reported for American and European patient populations, similar data have been lacking for Canadians with these diseases.
We sought to characterize the natural history of disease in a sample of Canadians with a history of moderate to severe psoriasis, with or without diagnosed PsA or other recognized comorbid conditions, and to identify factors that influenced their perception of psoriasis as a problem in their daily lives.
A nationwide telephone survey, pSoriasis Knowledge IN Canada (SKIN), was conducted between April 30 and June 2, 2007, on 500 people who indicated that they had been diagnosed with psoriasis and that their skin lesions had at some time affected an area at least as large as three palms of their hand (3% of body surface area [BSA]).
The mean age at diagnosis for psoriasis among SKIN survey respondents was 28 years, with 31% (155 of 500) indicating that they developed the disease prior to age 18 years. At the time of the survey, 54% (269 of 500) of respondents were experiencing lesions affecting a BSA equivalent to at least three palms (3%). In response to questions on the burden of illness, 35% (176 of 500) of respondents indicated that they considered psoriasis to be a substantial problem in their daily life. Both affected BSA at the time of the survey and self-reported extent of skin involvement at the height of the condition (BSAmax) correlated with the perception of psoriasis as a substantial problem. Other subpopulations in which psoriasis was commonly identified as a substantial problem included women and individuals with diagnosed PsA. Whereas 18% (88 of 500) of respondents were diagnosed with PsA, the number who reported joint pain or stiffness was substantially higher (51%; 256 of 500), suggesting that some respondents may have had incipient or undiagnosed PsA.
This survey reveals that psoriasis, PsA, and their associated comorbidities impose a severe burden on the daily lives of Canadians with a history of moderate to severe psoriasis.
尽管已经有一些针对美国和欧洲患者群体的、关于银屑病及银屑病关节炎（PsA）相关疾病负担的数据报道，但加拿大患有这些疾病的患者却缺乏类似数据。
我们试图描述患有中度至重度银屑病病史的加拿大人样本中疾病的自然史，无论是否诊断为PsA或其他公认的合并症，并确定影响他们将银屑病视为日常生活中一个问题的认知的因素。
2007年4月30日至6月2日，在全国范围内进行了一项电话调查，即加拿大银屑病知识调查（SKIN），调查对象为500名表示已被诊断患有银屑病且其皮肤病变在某些时候累及的面积至少相当于其三个手掌大小（体表面积[BSA]的3%）的人。
SKIN调查受访者中银屑病的平均诊断年龄为28岁，31%（500人中的155人）表示他们在18岁之前就患上了这种疾病。在调查时，54%（500人中的269人）的受访者有累及面积相当于至少三个手掌（3%）的病变。在关于疾病负担的问题中，35%（500人中的176人）的受访者表示他们认为银屑病在日常生活中是一个重大问题。调查时的受累BSA以及病情最严重时自我报告的皮肤受累程度（BSAmax）均与将银屑病视为重大问题的认知相关。其他银屑病通常被视为重大问题的亚群体包括女性和诊断为PsA的个体。虽然18%（500人中的88人）的受访者被诊断为PsA，但报告有关节疼痛或僵硬的人数要高得多（51%；500人中的256人），这表明一些受访者可能患有早期或未被诊断的PsA。
这项调查表明，银屑病、PsA及其相关合并症给有中度至重度银屑病病史的加拿大人的日常生活带来了沉重负担。
