Department of Ophthalmology, University Hospital Principe de Asturias, Madrid, Spain.
Cornea. 2009 Dec;28(10):1135-8. doi: 10.1097/ICO.0b013e3181a3c548.
To determine the effect of mitomycin C (MMC) on the corneal endothelium after primary pterygium surgery.
This prospective, interventional, nonrandomized, observer-masked study included 46 consecutive patients (51 eyes) with primary pterygium. The bare sclera technique with 1-minute application of 0.02% MMC intraoperatively was used in all cases. The follow-up period was 3 months. Preoperative and postoperative central corneal specular microscopy was performed. The endothelial cell density, coefficient of variation of cell size, and percentage of hexagonal cells were analyzed, and the corneal thickness was measured.
The mean endothelial cell densities preoperatively and 3 months postoperatively were 2382.35 +/- 342.07 cells per square millimeter (range, 1020-3129) and 2385.02 +/- 356.83 cells per square millimeter (range, 1001-3151), respectively (P = 0.96). The mean coefficients of variation of cell size preoperatively and 3 months postoperatively were 34.31 +/- 5.62 (range, 22-49) and 35.29 +/- 7.50 (range, 22-55), respectively (P = 0.17). The mean percentages of hexagonal cells values preoperatively and 3 months postoperatively were 52.98 +/- 7.32 (range, 32-71) and 51.61 +/- 8.98 (range, 32-67), respectively (P = 0.48). The mean pachymetry measurements preoperatively and 3 months postoperatively were 506.65 +/- 36.87 microm (range, 411-583) and 502.08 +/- 41.33 microm (range, 411-593), respectively (P = 0.99).
One intraoperative application of 0.02% MMC for 1 minute after primary pterygium surgery does not seem to cause substantial changes in the corneal endothelium at 3 months.
研究原发性翼状胬肉手术后应用丝裂霉素 C（MMC）对角膜内皮的影响。
本前瞻性、干预性、非随机、观察者设盲研究纳入 46 例（51 眼）原发性翼状胬肉患者。所有患者均采用单纯性巩膜暴露术，术中应用 0.02%MMC 1 分钟。随访 3 个月。术前和术后分别行角膜内皮镜检查，分析角膜内皮细胞密度、细胞大小变异系数和六角形细胞百分比，并测量角膜厚度。
术前和术后 3 个月角膜内皮细胞密度分别为 2382.35±342.07 个/平方毫米（范围：1020-3129）和 2385.02±356.83 个/平方毫米（范围：1001-3151）（P=0.96）。术前和术后 3 个月角膜细胞大小变异系数分别为 34.31±5.62（范围：22-49）和 35.29±7.50（范围：22-55）（P=0.17）。术前和术后 3 个月六角形细胞百分比分别为 52.98±7.32（范围：32-71）和 51.61±8.98（范围：32-67）（P=0.48）。术前和术后 3 个月角膜厚度分别为 506.65±36.87μm（范围：411-583）和 502.08±41.33μm（范围：411-593）（P=0.99）。
原发性翼状胬肉手术后，应用 0.02%MMC 1 分钟，术中单次使用似乎不会在术后 3 个月内对角膜内皮造成明显改变。
