Lohsiriwat Darin, Chinswangwatanakul Vitoon, Lohsiriwat Varut, Leelaratsamee Amorn
Department of Surgery, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
J Med Assoc Thai. 2009 Sep;92(9):1167-70.
The aim of the present study was to evaluate the efficacy and safety of parenteral amoxycillin/ clavulanate for the prevention of surgical site infection (SSI) following intra-abdominal surgery.
This prospective opened non-comparative clinical trial was conducted in the Department of Surgery, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand between 1 April 2004 and 30 September 2004. Prophylactic amoxycillin/clavulanate (Cavumox) at a dose of 1.2 gram was given intravenously to all patients who underwent emergency or elective intra-abdominal procedures. All patients were scheduled to follow-up visits at 7, 14 and 30 days post operatively for monitoring the occurrence of SSI.
Thirty emergency appendectomies (85.7%) and other 5 elective surgical procedures (14.3%) were performed in 35 patients including 14 males and 21 females with a mean age of 37 (range, 18-72) years. No SSI or drug allergy was observed.
Parenteral amoxycillin/clavulanate is a safe and effective antibiotic as the monotherapy for prevention of SSI following intra-abdominal surgery.
本研究旨在评估静脉注射阿莫西林/克拉维酸预防腹部手术后手术部位感染（SSI）的有效性和安全性。
本前瞻性开放性非对照临床试验于2004年4月1日至2004年9月30日在泰国曼谷诗里拉吉医院医学院外科进行。所有接受急诊或择期腹部手术的患者均静脉注射1.2克预防性阿莫西林/克拉维酸（凯维可）。所有患者均计划在术后7天、14天和30天进行随访，以监测SSI的发生情况。
35例患者共进行了30例急诊阑尾切除术（85.7%）和其他5例择期手术（14.3%），其中男性14例，女性21例，平均年龄37岁（范围18 - 72岁）。未观察到SSI或药物过敏情况。
静脉注射阿莫西林/克拉维酸作为预防腹部手术后SSI的单一疗法是一种安全有效的抗生素。
