用于固氮的钼运输
Molybdenum trafficking for nitrogen fixation.
作者信息
Hernandez Jose A, George Simon J, Rubio Luis M
机构信息
Department of Biochemistry, Midwestern University, Glendale, Arizona 85308, USA.
出版信息
Biochemistry. 2009 Oct 20;48(41):9711-21. doi: 10.1021/bi901217p.
Abstract
The molybdenum nitrogenase is responsible for most biological nitrogen fixation, a prokaryotic metabolic process that determines the global biogeochemical cycles of nitrogen and carbon. Here we describe the trafficking of molybdenum for nitrogen fixation in the model diazotrophic bacterium Azotobacter vinelandii. The genes and proteins involved in molybdenum uptake, homeostasis, storage, regulation, and nitrogenase cofactor biosynthesis are reviewed. Molybdenum biochemistry in A. vinelandii reveals unexpected mechanisms and a new role for iron-sulfur clusters in the sequestration and delivery of molybdenum.
摘要
钼固氮酶负责大部分生物固氮作用，这是一个原核生物代谢过程，决定了全球氮和碳的生物地球化学循环。在此，我们描述了模式固氮细菌维涅兰德固氮菌中用于固氮的钼的运输过程。对参与钼摄取、稳态、储存、调节及固氮酶辅因子生物合成的基因和蛋白质进行了综述。维涅兰德固氮菌中的钼生物化学揭示了意想不到的机制以及铁硫簇在钼的螯合和传递中的新作用。
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