De Weck A L
Institute of Clinical Immunology, Inselspital, University of Bern, Switzerland.
Clin Exp Allergy. 1990 Aug;20 Suppl 2:51-4. doi: 10.1111/j.1365-2222.1990.tb02461.x.
Although antihistamines were usually considered as ineffective in asthma, the appearance of new more potent anti-'1-antagonists with no or less side-effects leads to a reassessment of their use. Although mediators and mechanisms other than histamine are involved in natural or provoked reactions to allergens in the skin, the nose or the lungs, the new anti-H1-antagonists have been shown to be effective. For some of these drugs, the effect may go beyond a mere H1-receptor blockade and involve impairment of mediator release from mast cells and/or an inhibiting effect on other cell types (e.g. eosinophils) implicated in the late-phase reactions. Quantitative kinetics evaluation of late-phase reactions in the skin and of their inhibition by anti-allergic drugs will be helped considerably by the development of telethermography, a new skin evaluation technique.
尽管抗组胺药通常被认为对哮喘无效，但新型更有效的无副作用或副作用较小的抗H1拮抗剂的出现促使人们重新评估其用途。虽然除组胺外的介质和机制也参与皮肤、鼻子或肺部对过敏原的自然或诱发反应，但新型抗H1拮抗剂已被证明是有效的。对于其中一些药物，其作用可能不仅仅是单纯的H1受体阻断，还包括抑制肥大细胞释放介质和/或对参与迟发反应的其他细胞类型（如嗜酸性粒细胞）产生抑制作用。远程热成像技术作为一种新的皮肤评估技术的发展，将极大地有助于对皮肤迟发反应及其被抗过敏药物抑制情况进行定量动力学评估。
